AI-ECG: interpreting electrocardiograms for clinical decision-making

Electrocardiograms (ECGs) are a cheap and ubiquitous measure of the electrical activity of the heart. Advances in AI have demonstrated enormous prognostic value in these tests, above and beyond what clinicians and traditional computerized approaches have yielded. Our work develops and evaluates AI-ECG technology that turns routine electrocardiograms into clinically useful predictions. We study cardiac dysfunction, mortality, and longitudinal risk across pediatric and adult congenital heart disease, with an emphasis on robust, multicenter evaluation and practical clinical decision support.

Interpreting AI-ECG models, from Mayourian et al. Circulation 2024
Interpreting AI-ECG models, from Mayourian et al. Circulation 2024

Related Posts

Selected Papers

Electrocardiogram-based deep learning to predict left ventricular systolic dysfunction in paediatric and adult congenital heart disease in the USA: a multicentre modelling study
Joshua Mayourian, Ivor B. Asztalos, Amr El-Bokl, Platon Lukyanenko, Ryan L. Kobayashi, William G. La Cava, Sunil J. Ghelani, Victoria L. Vetter, John K. Triedman (2025)
The Lancet Digital Health
Electrocardiogram-based deep learning to predict mortality in paediatric and adult congenital heart disease
Joshua Mayourian, Amr El-Bokl, Platon Lukyanenko, William G. La Cava, Tal Geva, Anne Marie Valente, John K Triedman, Sunil J Ghelani (2025)
European Heart Journal
Deep survival analysis from adult and pediatric electrocardiograms: a multi-center benchmark study
Platon Lukyanenko, Joshua Mayourian, Mingxuan Liu, John K. Triedman, Sunil J. Ghelani, William G. La Cava (2025)
BioData Mining
Deep Learning-Based Electrocardiogram Analysis Predicts Biventricular Dysfunction and Dilation in Congenital Heart Disease
Joshua Mayourian, Addison Gearhart, William G. La Cava, Akhil Vaid, Girish N. Nadkarni, John K. Triedman, Andrew J. Powell, Rachel M. Wald, Anne Marie Valente, Tal Geva, Son Q. Duong, Sunil J. Ghelani (2024)
Journal of the American College of Cardiology (JACC)
An ECG foundation model for generalizable cardiac function prediction across the lifespan
Yuting Yang, Lorenzo Peracchio, Joshua Mayourian, Timothy Miller, William G. La Cava (2026)
medRxiv