Interpretable Prediction Models

Some AI models do not need to be explained; evidence of their reliability is enough. But when it comes to many medical applications of AI, the explainability of models is often crucial. This view is shared by the FDA, where regulatory guidelines state ML recommendations must enable a health care provider “… to independently review the basis for such recommendations”.

Although AI systems may be complex, the clinical models produced by them need not be. We investigate state-of-the-art methods (symbolic regression, neurosymbolic AI, and large language models (LLMs)) as tools to generate simple clinical models that clinicians can use to better understand and treat their patients.

An interpretable model of treatment resistant hypertension from La Cava et al. *npj Digital Medicine* 2023
An interpretable model of treatment resistant hypertension from La Cava et al. npj Digital Medicine 2023

Code

  • Feature Engineering Automation Tool
  • Brush: an Interpretable Machine Learning Library
  • Funding

  • PCORI
  • Related Posts

    Selected Papers

    A flexible symbolic regression method for constructing interpretable clinical prediction models
    William G. La Cava, Paul C. Lee, Imran Ajmal, Xiruo Ding, Priyanka Solanki, Jordana B. Cohen, Jason H. Moore, Daniel S. Herman (2023)
    npj Digital Medicine
    Inexact Simplification of Symbolic Regression Expressions with Locality-sensitive Hashing
    Guilherme Seidyo Imai Aldeia, Fabricio Olivetti de Franca, William G. La Cava (2024)
    Proceedings of the Genetic and Evolutionary Computation Conference
    Learning concise representations for regression by evolving networks of trees
    William La Cava, Tilak Raj Singh, James Taggart, Srinivas Suri, Jason H. Moore (2019)
    International Conference on Learning Representations
    Interpretation of machine learning predictions for patient outcomes in electronic health records
    William La Cava, Christopher R. Bauer, Jason H. Moore, Sarah A. Pendergrass (2019)
    AMIA Annual Symposium
    Epsilon-Lexicase Selection for Regression
    William La Cava, Lee Spector, Kourosh Danai (2016)
    Proceedings of the Genetic and Evolutionary Computation Conference 2016